Single sublethal dose of microcystin-LR is responsible for different alterations in biochemical, histological and physiological renal parameters
نویسندگان
چکیده
منابع مشابه
Sublethal Microcystin Exposure and Biochemical Outcomes among Hemodialysis Patients
Cyanobacteria are commonly-occurring contaminants of surface waters worldwide. Microcystins, potent hepatotoxins, are among the best characterized cyanotoxins. During November, 2001, a group of 44 hemodialysis patients were exposed to microcystins via contaminated dialysate. Serum microcystin concentrations were quantified with enzyme-linked immunosorbent assay which measures free serum microcy...
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Cyanobacteria produce metabolites with diverse bioactivities, structures and pharmacological properties. The effects of microcystins (MCYs), a family of peptide type protein-phosphatase inhibitors and cylindrospermopsin (CYN), an alkaloid type of protein synthesis blocker will be discussed in this review. We are focusing mainly on cyanotoxin-induced changes of chromatin organization and their p...
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Microcystins and nodularin are potent hepatotoxins produced by fresh and seawater cyanobacteria. The persistence of three hepatotoxins – microcystin-LR, microcystin-RR and nodularin – was investigated in sterile BG-11 medium of different salinity and in water collected from the Gulf of Gdańsk. After 21 days of incubation at 17± 1◦C and constant illumination of about 40 μmol photon m−2 s−1 the c...
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ژورنال
عنوان ژورنال: Toxicon
سال: 2012
ISSN: 0041-0101
DOI: 10.1016/j.toxicon.2012.02.003